Rytis Prekeris Lab

 

 

 

2026​

Sachs, R., Ogi, Y., and Prekeris, R. (2026) TPGS1 regulates central spindle microtubule glutamylation and remodeling during telophase and anaphase. EMBO Reports. In Press. PMID: 41872551

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2025

Sampath, R., Vaeth, K., Mikalayeva, V., Skeberdis, V.A., Prekeris, R*., and Han, K.J*. (2025) Rab40 GTPases regulate AMBRA1-mediated transcription and cell migration. Journal of Cell Science. 138(7):jcs263707. PMID:40110710

 

Neuman, A., Sampath, R., and Prekeris, R. (2025) Rap1 activity and localization is regulated by Rab40/CRL5 facilitated mono-ubiquitylation. microPublication Biology. In Press.

 

Dahms, P.A., Hinckley, B., Prekeris, R., Behbod, F., and Lyons, T.R. (2025) Semaphorin-7A promotes macrophage-mediated mammary epithelial and ductal carcinoma in situ invasion. Breast Cancer Research. In Press. PMID: 41454324

 

Neumann, A., Sampath, R., Mayerhofer, E., Mikalayeva, V., Skeberdis, V.A., Sarapniene, I., and Prekeris, R. (2025) Ubiquitylation-dependent Rap2 activation regulates lamellipodia dynamics during cell migration. Journal of Cell Science. 138(23):jcs264375. PMID:41200767

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2024

Hoffman, H.K. and Prekeris, R. (2024) HOPS-dependent lysosomal function controls Rab19 availability for ciliogenesis in polarized epithelial cells. Journal of Cell Science. 137(5):jcs261047. PMID:37665101

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Ceglowski, J., Hoffman, H.K., Neumann, A., Hoff, K.J., McCurdy, B.L., Moore, J.K., and Prekeris, R. (2023) TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells. EMBO Reports. In Press. PMID:38177908

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2023

Jewett, C.E., McCurdy, B.L., O’Toole, E.T., Stemm-Wolf, A.J., Lin, C.H., Olsen, V., Martin, W. Reinholdt, L., Espinosa, J.M., Sullivan, K.D., Macklin, W.B., Prekeris, R., and Person, C.G. (2023) Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. eLife. 12:e78202, PMID: 36656118

 

Lencer, E., Rains, A., Binne, E., Prekeris, R., and Artinger, K. (2023) Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish. Development. 150(14):dev201304. PMID: 37390228

 

Farmer, T., Vaeth, K.F., Han, K.J., Goering, R., Taliaferro, J.M., and Prekeris, R. (2023) The Role of Midbody-Associated mRNAs in Regulating Abscission. Journal of Cell Biology. 222(12):e202306123. PMID:37922419

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​Neumann, A., and Prekeris, R. (2023) A Rab-bit hole: Rab40 GTPases as new regulators of the actin cytoskeleton and cell migration. Frontiers in Cell and Developmental Biology. doi: 10.3389/fcell.2023.1268922. PMID:37736498

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2022

Duncan, E.D., Han, K.J., Trout M.A. and Prekeris, R. (2022) Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration. Journal of Cell Biology. 221(4):e202107114. PMID: 35293963

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Han, K.J., Mikalayeva, V., Gerber, S.A., Kettenbach, A.N., Skeberdis, V.A., and Prekeris, R. (2022) Rab40c regulates Focal Adhesions and PP6 activity by controlling ANKRD28 ubiquitylation. Life Science Alliance. In Press. PMID: 35512830

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Farmer, T., and Prekeris, R. (2022) New signaling kid on the block: The role of the post-mitotic midbody in polarity, stemness, and proliferation. Molecular Biology of the Cell. 33(3), PMID:35179994

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Hoffman, H.K. and Prekeris, R. (2022) pathways of ciliogenesis and regulation by actin cytoskeleton. Journal of Cell Science. In Press. PMID: 35575063

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2021

Gibieza, P., Peterman, E., Hoffman, H.K., Van Engeleburg, S., Skeberdis, V.A., and Prekeris, R. (2021) Rab14/MACF2 complex regulates endosomal targeting during cytokinesis. Molecular Biology of the Cell. In Press.

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Jewett, C.E., Soh, A.W.J., Lin, C.H., Lencer, E., Westlake, C.J., Pearson, C.G., and Prekeris, R. (2021) Rab19 directs cortical remodeling and membrane growth for primary ciliogenesis. Developmental Cell. 56(3):325-340.

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Linklater, E.S., Duncan, E.D., Han, K.J., Kaupinis, A., Valius, M., Lyons, T.R. and Prekeris, R. (2021) Rab40/Cullin5 complex regulate EPLIN and actin cytoskeleton dynamics during cell migration and invasion. Journal of Cell Biology. In Press.

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2020

Peterman, E., Valius, M., and Prekeris, R. (2020) CLICK4 is a cytokinesis cleavage furrow protein that regulates cortical cytoskeleton stability during cell division. Journal of Cell Science. 133(9). PMID: 32184265.

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Jewett, C.E., Appel, B.H., and Prekeris, R. (2020) The Rab11 effectors Fip5 and Fip1 regulate zebrafish intestinal development. Biology Open. In Press.

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2019

 Peterman, E., Gibieza, P., Schafer, J., Skeberdis, A., Kaupinis, A., Valius, M., Heiligenstein, X., Hurbain, I., Raposo, G., and Prekeris, R. (2019) The Post-Abscission Midbody is an Intracellular Signaling Organelle that Regulates Cell Proliferation. Nature Communications. 18;10(1):318. PMID: 31320617

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Peterman, E., and Prekeris, R. (2019) The post mitotic midbody: Regulating polarity, stemless, and proliferation. Journal of Cell Biology. 218(12):3903-3911. PMID: 31690620

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